張邵涵
助理教授
現職
東吳大學資料科學系專案助理教授
研究領域
研究聚焦於複雜生物系統與社會空間系統之時空動態 (spatiotemporal dynamics)。研究方法結合資料科學、神經科學與生醫資料分析，運用機器學習與高維資料分析技術，解析神經訊號、生物分子資料與都市空間資料中的時間與空間結構特徵。
主要領域包含：
- Computational Neuroscience（計算神經科學）
- 神經訊號與生物資料之時間序列分析 (time-series analysis)
- 神經精神疾病（如 Post-Traumatic Stress Disorder, PTSD）相關之神經機制與生物標記與免疫研究
- Biomedical Data Science（生物醫學資料科學）
- 高維單細胞資料分析 (如:質譜流式細胞術 (Mass Cytometry, Cytometry by Time-of-Flight, CyTOF)
- 生理訊號與多組學資料（proteomics 與 transcriptomics）之整合分析
3.Socio-Spatial Data Science（社會空間資料科學）
課程
- 時序分析 (Time Series Analysis)
-
神經精神疾病之研究 (Neuropsychiatric Disorders)
- 創傷後壓力症候群（Post-Traumatic Stress Disorder, PTSD）神經機制研究
- 腦波訊號（Electroencephalography, EEG）、基因表現資料（gene expression data）與行為資料之整合分析
- 機器學習方法於神經精神疾病預測、分類與生物標記探索之應用
-
高維單細胞免疫資料分析 (High-Dimensional Single-Cell Immune Data Analysis)
- 質譜流式細胞術（Mass Cytometry, Cytometry by Time-of-Flight, CyTOF）之高維免疫表型分析
- 神經免疫交互作用（neuro-immune interactions）之研究
-
生物訊號與機器學習建模 (Biosignal Analysis and Machine Learning Modeling)
- 腦波（Electroencephalography, EEG）與局部場電位（Local Field Potentials, LFP）之生理訊號分析
- 時序資料建模與預測（Time-Series Modeling and Prediction）
- 神經網路模型
-
文化與都市空間資料分析 (Cultural and Urban Spatial Data Analysis)
- 藝術機構與空間資料之關聯分析與建模
學歷
- 國立成功大學 / 中央研究院— 博士 (Ph.D.)
跨領域神經科學國際研究生博士學程
Taiwan International Graduate Program in Interdisciplinary Neuroscience
National Cheng Kung University / Academia Sinica
(2016–2023) - 國立臺灣大學— 碩士 (M.S.)
動物學研究所 神經科學組
Graduate Institute of Zoology (Neuroscience)
National Taiwan University
(2010–2012) - 東吳大學 微生物學系— 學士 (B.S.)
Department of Microbiology
Soochow University
(2006–2010)
經歷
- 博士後研究員 (Postdoctoral Research Fellow)
中央研究院 生物醫學科學研究所
Institute of Biomedical Sciences, Academia Sinica, Taiwan
- 2025｜受邀擔任會議主持人 (Invited Session Chair)
國際神經精神藥理學學院世界大會暨亞洲神經精神藥理學學院聯合會議
World Congress of Neuropsychopharmacology – CINP–AsCNP Joint Congress
（Collegium Internationale Neuro-Psychopharmacologicum / Asian College of Neuropsychopharmacology）
澳洲墨爾本 (Melbourne, Australia)
- 2022｜國際神經精神藥理學學院海報論文獎
Collegium Internationale Neuro-Psychopharmacologicum (CINP)
國際神經精神藥理學學院世界大會
World Congress of Neuropsychopharmacology
海報論文獎 (Poster Award) - 2022｜歐洲神經科學學會聯盟 / 國際腦研究組織研究獎助金
Federation of European Neuroscience Societies / International Brain Research Organization (FENS–IBRO)
歐洲神經科學學會聯盟 / 國際腦研究組織情緒神經科學暑期學校
Summer School on Affective Neuroscience
研究獎助金 (FENS–IBRO Grant) - 2020｜歐洲神經科學學會聯盟研究獎助金
Federation of European Neuroscience Societies (FENS)
歐洲神經科學學會聯盟線上論壇
FENS Virtual Forum
研究獎助金 (FENS Grant) - 2020｜中央研究院台灣國際研究生學程研究獎助金
Academia Sinica Taiwan International Graduate Program (AS-TIGP)
研究績效獎學金 (Research Performance Fellowship) - 2019｜中央研究院生物醫學科學研究所海報論文獎
Institute of Biomedical Sciences, Academia Sinica (IBMS)
中央研究院研究日
Academia Sinica Research Day
海報論文獎 (Poster Award) - 2012｜國立臺灣大學海報論文獎
National Taiwan University
海報論文獎
Publications
- Lu, C.H., Tsai, C.H., Phillip, I.O., Chiang, P.C., Chang, S.H*., Chen, H.Y., Weng, H.J., Liang, P.H., Chen, S.Y., Liu, F.T., Tsai, T.F., & Lee, Y.L. (2025). Narrowband ultraviolet B induces peripheral regulatory T cells to exert antigen‐specific immune suppression. Allergy.
IF: 12.4; Ranking: 2/29 (Top 7%, Q1) in Allergy. - Chang, S.H.*, Chang, Y.M., Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2025). Temporal profiling of posttraumatic stress disorder (PTSD) explored by brain wave dynamics, machine learning, and genetic patterns in a rat model simulating PTSD. The International Journal of Neuropsychopharmacology, Advance online publication.
IF: 4.5; Ranking: 43/277 (Q1) in Pharmacology & Pharmacy. - Chang, S.H.*, Chang, Y.M., Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2023). Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model. Neurobiology of Stress, 27, 100569.
IF: 5.2; Ranking: 11/53 (Q1) in Behavioral Sciences. - Chang, S.H.*, Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2023). Early- and late-phase changes of brain activity and early-phase neuromodulation in the posttraumatic stress disorder rat model. Neurobiology of Stress, 26, 100554.
IF: 5.2; Ranking: 11/53 (Q1) in Behavioral Sciences. - Kuok, C.M., Liu, J.R., Liang, J.S., Chang, S.H*., and Yang, M.T. (2022). Sleep problems in preschool children at the child development center with different developmental status: A questionnaire survey. Front Pediatr 10, 949161.
IF: 2.1; Ranking: 57/130 (Q2) in Pediatrics. - Chang SH*and, Shyu BC. (2022) The Temporal Development and a Staging Approach of Post-Traumatic Stress Disorder. Horizons in Neuroscience Research. ISBN: 978-1-68507-679-5, Nova Science Publishers, Inc., New York.
- British Neuroscience Association (BNA) 2021 Festival of Neuroscience Poster abstracts. Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder (2021). Brain and Neuroscience Advances.
- Chang, S.H.*, Yu, Y.H., He, A., Ou, C.Y., Shyu, B.C., and Huang, A.C.W. (2021). BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behav Neurol 2021, 6657716.
IF: 2.9; Ranking: 182/272 (Q3) in Neurosciences. - H. Lin, R.S. Yang, K.C. Wang, D.H. Lu, H. C. Liou, Y. Ma, S. H. Chang*, and W. M. Fu, “Ethanol Extracts of Fresh Davallia formosana (WL1101) Inhibit Osteoclast Differentiation by Suppressing RANKL-Induced Nuclear Factor-κB Activation” (2013) Evid Based Complement Alternat Med., 2013: 647189.a
IF: 2.6; Ranking: Q2 in Integrative & Complementary Medicine. - Laboratory Animal Center Quarterly No.006: ICR Mice Complete Blood Count Analysis and Comparison（2015-11-23）
- Laboratory Animal Center Quarterly No.005: Introduction of Complete Blood Count and Hematology Analyzer（2015-08-10）
- Laboratory Animal Center Quarterly No.003: Laboratory Animal Health Monitoring by Molecular-Based Methods（2015-02-10）
Conference presentation
International Conference Presentation:
- 2025, Chang SH*, Chen HY. Exploring CyTOF for extracellular vesicle potency assessment: A framework for high-dimensional functional immunophenotyping. Society for Clinical Research and Translation of Extracellular Vesicles Singapore (SOCRATES) Annual Meeting, Singapore.
- 2025, Chang SH*. Session Chair, Poster Session 3: Bipolar Disorders, OCD, PTSD, Variable. CINP–AsCNP 2025 Joint Congress: 36th World Congress of Neuropsychopharmacology / 9th AsCNP Congress, Melbourne, Australia. (Invited Chair)
- 2024, Chang SH*, Shaw FZ, Shyu BC. Temporal profiling of posttraumatic stress disorder (PTSD) explored by brain wave dynamics, machine learning, and genetic patterns in a rat model simulating PTSD. 35th World Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Tokyo, Japan.
- 2024, Chang SH*, Shaw FZ, Shyu BC. Applying machine learning for fear detection and prediction in a rat model simulating post-traumatic stress disorder. 37th European College of Neuropsychopharmacology (ECNP) Congress, Milan, Italy.
- 2022, Chang SH*, Shaw FZ, Shyu BC. Early- and late-phase alternations of the brain wave activity and early-phase intervention of neuromodulation in the post-traumatic stress disorder rat model. Neuroscience 2022 (Virtual Forum).
- 2022, Lin CY, Chang SH*, Shyu BC. The detection and prediction of traumatic stress-related fears by the methods of machine learning in a rat model of post-traumatic stress disorder (PTSD). 2022 INCF Neuroinformatics Assembly.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress-Related Fears in a Rat Model of Post-Traumatic Stress Disorder. 2022 13th FENS Forum of Neuroscience. Paris, France.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress-Related Fears in a Rat Model of Post-Traumatic Stress Disorder. 2022 European Neuroscience Conference for Doctoral Students (ENCODS). Paris, France.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The temporal profiles of frontal gene expression compared in the rat model of post-traumatic stress disorder (PTSD) and the conditioned fear model. The International College of Neuropsychopharmacology. Taipei, Taiwan.
- 2021, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, ENCODS 2021 – European Neuroscience Conference by Doctoral Students (Virtual Forum).
- 2021, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, British Neuroscience Association (BNA) 2021 Festival of Neuroscience (Virtual Forum).
- 2020, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, Federation of European Neuroscience Societies (FENS) 2020 Virtual Forum.
- 2019, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, 3rd Biennial International Convention of Psychological Science, Paris, France.
- 2018, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, Annual Meeting of the Association for the Study of Neurons and Diseases (AND), Taipei, Taiwan.
張邵涵
助理教授
現職
東吳大學資料科學系專案助理教授
研究領域
研究聚焦於複雜生物系統與社會空間系統之時空動態 (spatiotemporal dynamics)。研究方法結合資料科學、神經科學與生醫資料分析，運用機器學習與高維資料分析技術，解析神經訊號、生物分子資料與都市空間資料中的時間與空間結構特徵。
主要領域包含：
- Computational Neuroscience（計算神經科學）
- 神經訊號與生物資料之時間序列分析 (time-series analysis)
- 神經精神疾病（如 Post-Traumatic Stress Disorder, PTSD）相關之神經機制與生物標記與免疫研究
- Biomedical Data Science（生物醫學資料科學）
- 高維單細胞資料分析 (如:質譜流式細胞術 (Mass Cytometry, Cytometry by Time-of-Flight, CyTOF)
- 生理訊號與多組學資料（proteomics 與 transcriptomics）之整合分析
3.Socio-Spatial Data Science（社會空間資料科學）
課程
- 時序分析 (Time Series Analysis)
-
神經精神疾病之研究 (Neuropsychiatric Disorders)
- 創傷後壓力症候群（Post-Traumatic Stress Disorder, PTSD）神經機制研究
- 腦波訊號（Electroencephalography, EEG）、基因表現資料（gene expression data）與行為資料之整合分析
- 機器學習方法於神經精神疾病預測、分類與生物標記探索之應用
-
高維單細胞免疫資料分析 (High-Dimensional Single-Cell Immune Data Analysis)
- 質譜流式細胞術（Mass Cytometry, Cytometry by Time-of-Flight, CyTOF）之高維免疫表型分析
- 神經免疫交互作用（neuro-immune interactions）之研究
-
生物訊號與機器學習建模 (Biosignal Analysis and Machine Learning Modeling)
- 腦波（Electroencephalography, EEG）與局部場電位（Local Field Potentials, LFP）之生理訊號分析
- 時序資料建模與預測（Time-Series Modeling and Prediction）
- 神經網路模型
-
文化與都市空間資料分析 (Cultural and Urban Spatial Data Analysis)
- 藝術機構與空間資料之關聯分析與建模
學歷
- 國立成功大學 / 中央研究院— 博士 (Ph.D.)
跨領域神經科學國際研究生博士學程
Taiwan International Graduate Program in Interdisciplinary Neuroscience
National Cheng Kung University / Academia Sinica
(2016–2023) - 國立臺灣大學— 碩士 (M.S.)
動物學研究所 神經科學組
Graduate Institute of Zoology (Neuroscience)
National Taiwan University
(2010–2012) - 東吳大學 微生物學系— 學士 (B.S.)
Department of Microbiology
Soochow University
(2006–2010)
經歷
- 博士後研究員 (Postdoctoral Research Fellow)
中央研究院 生物醫學科學研究所
Institute of Biomedical Sciences, Academia Sinica, Taiwan
- 2025｜受邀擔任會議主持人 (Invited Session Chair)
國際神經精神藥理學學院世界大會暨亞洲神經精神藥理學學院聯合會議
World Congress of Neuropsychopharmacology – CINP–AsCNP Joint Congress
（Collegium Internationale Neuro-Psychopharmacologicum / Asian College of Neuropsychopharmacology）
澳洲墨爾本 (Melbourne, Australia)
- 2022｜國際神經精神藥理學學院海報論文獎
Collegium Internationale Neuro-Psychopharmacologicum (CINP)
國際神經精神藥理學學院世界大會
World Congress of Neuropsychopharmacology
海報論文獎 (Poster Award) - 2022｜歐洲神經科學學會聯盟 / 國際腦研究組織研究獎助金
Federation of European Neuroscience Societies / International Brain Research Organization (FENS–IBRO)
歐洲神經科學學會聯盟 / 國際腦研究組織情緒神經科學暑期學校
Summer School on Affective Neuroscience
研究獎助金 (FENS–IBRO Grant) - 2020｜歐洲神經科學學會聯盟研究獎助金
Federation of European Neuroscience Societies (FENS)
歐洲神經科學學會聯盟線上論壇
FENS Virtual Forum
研究獎助金 (FENS Grant) - 2020｜中央研究院台灣國際研究生學程研究獎助金
Academia Sinica Taiwan International Graduate Program (AS-TIGP)
研究績效獎學金 (Research Performance Fellowship) - 2019｜中央研究院生物醫學科學研究所海報論文獎
Institute of Biomedical Sciences, Academia Sinica (IBMS)
中央研究院研究日
Academia Sinica Research Day
海報論文獎 (Poster Award) - 2012｜國立臺灣大學海報論文獎
National Taiwan University
海報論文獎
Publications
- Lu, C.H., Tsai, C.H., Phillip, I.O., Chiang, P.C., Chang, S.H*., Chen, H.Y., Weng, H.J., Liang, P.H., Chen, S.Y., Liu, F.T., Tsai, T.F., & Lee, Y.L. (2025). Narrowband ultraviolet B induces peripheral regulatory T cells to exert antigen‐specific immune suppression. Allergy.
IF: 12.4; Ranking: 2/29 (Top 7%, Q1) in Allergy. - Chang, S.H.*, Chang, Y.M., Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2025). Temporal profiling of posttraumatic stress disorder (PTSD) explored by brain wave dynamics, machine learning, and genetic patterns in a rat model simulating PTSD. The International Journal of Neuropsychopharmacology, Advance online publication.
IF: 4.5; Ranking: 43/277 (Q1) in Pharmacology & Pharmacy. - Chang, S.H.*, Chang, Y.M., Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2023). Time-course analysis of frontal gene expression profiles in the rat model of posttraumatic stress disorder and a comparison with the conditioned fear model. Neurobiology of Stress, 27, 100569.
IF: 5.2; Ranking: 11/53 (Q1) in Behavioral Sciences. - Chang, S.H.*, Chen, H.Y., Shaw, F.Z., & Shyu, B.C. (2023). Early- and late-phase changes of brain activity and early-phase neuromodulation in the posttraumatic stress disorder rat model. Neurobiology of Stress, 26, 100554.
IF: 5.2; Ranking: 11/53 (Q1) in Behavioral Sciences. - Kuok, C.M., Liu, J.R., Liang, J.S., Chang, S.H*., and Yang, M.T. (2022). Sleep problems in preschool children at the child development center with different developmental status: A questionnaire survey. Front Pediatr 10, 949161.
IF: 2.1; Ranking: 57/130 (Q2) in Pediatrics. - Chang SH*and, Shyu BC. (2022) The Temporal Development and a Staging Approach of Post-Traumatic Stress Disorder. Horizons in Neuroscience Research. ISBN: 978-1-68507-679-5, Nova Science Publishers, Inc., New York.
- British Neuroscience Association (BNA) 2021 Festival of Neuroscience Poster abstracts. Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder (2021). Brain and Neuroscience Advances.
- Chang, S.H.*, Yu, Y.H., He, A., Ou, C.Y., Shyu, B.C., and Huang, A.C.W. (2021). BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behav Neurol 2021, 6657716.
IF: 2.9; Ranking: 182/272 (Q3) in Neurosciences. - H. Lin, R.S. Yang, K.C. Wang, D.H. Lu, H. C. Liou, Y. Ma, S. H. Chang*, and W. M. Fu, “Ethanol Extracts of Fresh Davallia formosana (WL1101) Inhibit Osteoclast Differentiation by Suppressing RANKL-Induced Nuclear Factor-κB Activation” (2013) Evid Based Complement Alternat Med., 2013: 647189.a
IF: 2.6; Ranking: Q2 in Integrative & Complementary Medicine. - Laboratory Animal Center Quarterly No.006: ICR Mice Complete Blood Count Analysis and Comparison（2015-11-23）
- Laboratory Animal Center Quarterly No.005: Introduction of Complete Blood Count and Hematology Analyzer（2015-08-10）
- Laboratory Animal Center Quarterly No.003: Laboratory Animal Health Monitoring by Molecular-Based Methods（2015-02-10）
Conference presentation
International Conference Presentation:
- 2025, Chang SH*, Chen HY. Exploring CyTOF for extracellular vesicle potency assessment: A framework for high-dimensional functional immunophenotyping. Society for Clinical Research and Translation of Extracellular Vesicles Singapore (SOCRATES) Annual Meeting, Singapore.
- 2025, Chang SH*. Session Chair, Poster Session 3: Bipolar Disorders, OCD, PTSD, Variable. CINP–AsCNP 2025 Joint Congress: 36th World Congress of Neuropsychopharmacology / 9th AsCNP Congress, Melbourne, Australia. (Invited Chair)
- 2024, Chang SH*, Shaw FZ, Shyu BC. Temporal profiling of posttraumatic stress disorder (PTSD) explored by brain wave dynamics, machine learning, and genetic patterns in a rat model simulating PTSD. 35th World Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Tokyo, Japan.
- 2024, Chang SH*, Shaw FZ, Shyu BC. Applying machine learning for fear detection and prediction in a rat model simulating post-traumatic stress disorder. 37th European College of Neuropsychopharmacology (ECNP) Congress, Milan, Italy.
- 2022, Chang SH*, Shaw FZ, Shyu BC. Early- and late-phase alternations of the brain wave activity and early-phase intervention of neuromodulation in the post-traumatic stress disorder rat model. Neuroscience 2022 (Virtual Forum).
- 2022, Lin CY, Chang SH*, Shyu BC. The detection and prediction of traumatic stress-related fears by the methods of machine learning in a rat model of post-traumatic stress disorder (PTSD). 2022 INCF Neuroinformatics Assembly.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress-Related Fears in a Rat Model of Post-Traumatic Stress Disorder. 2022 13th FENS Forum of Neuroscience. Paris, France.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress-Related Fears in a Rat Model of Post-Traumatic Stress Disorder. 2022 European Neuroscience Conference for Doctoral Students (ENCODS). Paris, France.
- 2022, Chang SH*, Shaw FZ, Shyu BC. The temporal profiles of frontal gene expression compared in the rat model of post-traumatic stress disorder (PTSD) and the conditioned fear model. The International College of Neuropsychopharmacology. Taipei, Taiwan.
- 2021, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, ENCODS 2021 – European Neuroscience Conference by Doctoral Students (Virtual Forum).
- 2021, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, British Neuroscience Association (BNA) 2021 Festival of Neuroscience (Virtual Forum).
- 2020, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, Federation of European Neuroscience Societies (FENS) 2020 Virtual Forum.
- 2019, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, 3rd Biennial International Convention of Psychological Science, Paris, France.
- 2018, Chang SH*, Shaw FZ, Shyu BC. The Temporal Profiling and Modulation of
- Traumatic Stress Related Fears in a Rat Model of Post-Traumatic Stress Disorder, poster, Annual Meeting of the Association for the Study of Neurons and Diseases (AND), Taipei, Taiwan.
